At Irving, Texas, Tony Romo had a 15-yard touchdown run and threw touchdown passes of 59, 37 and 17 yards, turning what had been a tight early game into yet another easy win for Dallas and another frustrating loss for St. Louis.

The Cowboys are 4-0 for the first time since 1995, the year of their last Super Bowl title.

The Rams are 0-4 for the first time since 2002, when they opened with five straight defeats coming off a Super Bowl loss.

Giants 16, Eagles 3

At New Jersey, Osi Umenyiora had a team-record six sacks and the Giants (2-2) set a franchise record and tied a league mark by sacking Donovan McNabb 12 times.

With Hall of Famer Lawrence Taylor on hand as an honorary captain, Mathias Kiwanuka added three sacks, Justin Tuck two and Michael Strahan one in an awesome display by a defence that was ranked as the worst in the league after giving up 80 points in its first two games.

Raiders 35, Dolphins 17

At Miami, Daunte Culpepper ran for three touchdowns and threw for two to win against his former team.

Oakland Raiders quarterback Daunte Culpepper celebrates his third rushing touchdown [EPA]

For the second time in four years, the Dolphins are 0-4.

Culpepper threw only 12 times and completed five for 75 yards, but hit Jerry Porter for scores of 7 and 27 yards.

Justin Fargas replaced an injured LaMont Jordan shortly before halftime and ran for a career-high 179 yards in 22 carries.

Falcons 26, Texans 16

At Atlanta, Joey Harrington threw a pair of touchdown passes to Michael Jenkins, 47-year-old Morten Andersen kicked four field goals and the Falcons defeated Matt Schaub and the Texans.

Jenkins hauled in scoring passes of 5 and 7 yards, the first two-touchdown game of his up-and-down career. Harrington, who took over as starter after Schaub was traded and Michael Vick became embroiled in a dogfighting case, was 23-of-29 for 223 yards.

The NFL's oldest player, Andersen showed he's still got plenty of punch in his left leg by connecting from 28, 22, 36 and 46 yards for the Falcons
(1-3).

Browns 27, Ravens 13

At Cleveland, Derek Anderson threw two touchdown passes and Jamal Lewis ran for one against his former team.

With their second win over a division opponent this month, the Browns (2-2) looked nothing like the inept team that was embarrassed 34-7 in their home opener three weeks ago by Pittsburgh.

Lewis, released by Baltimore coach Brian Billick in March, got some satisfaction against his former coach and the team he played with for seven seasons.

He finished with 64 yards and scored on a disputed 1-yard dive in the second quarter, the first TD rushing given up by the NFL's top run defence this season.

Bills 17, Jets 14

At Orchard Park, New York, Trent Edwards went 22-of-28 for 234 yards, including a 1-yard touchdown to Michael Gaines with 7 minutes left, after making his first career start in place of injured J.P. Losman.

With the third-round draft pick, the Bills produced their most points, total yards (304), yards passing and first downs (19) of the season, and helped erase the frustrations of an 0-3 start that included two 20-point losses.

Jabari Greer's interception of Chad Pennington's pass at the Jets 25 set up Gaines' score that put Buffalo ahead 17-7. Terrence McGee's interception at the Bills 31 ended the Jets' last-gasp drive with 6 seconds remaining.

Lions 37, Bears 27

At Detroit, Jon Kitna threw two touchdown passes in the fourth quarter and Detroit overcame mistakes and missed opportunities to beat Chicago.

The Chicago Bears Muhsin Muhammad breaks through, but his team stumbles [EPA]

However, the onside kick bounced to Detroit's Casey FitzSimmons and he returned it for a TD.

It was the kind of game Detroit used to lose as the league's laughingstock, but these might not be the same-old Lions, who are 3-1.

The defending NFC champion Bears fell to 1-3. Chicago can only hope the slow start turns into a good season, as it did in 2005 when it lost three of the first four games and bounced back to finish 11-5.

Chiefs 30, Chargers 16

At San Diego, the Kansas City Chiefs shocked the Chargers, scoring 24 straight points in the second half and getting huge plays from two rookies.

Dwayne Bowe, the Chiefs' first-round draft pick, caught a go-ahead, 51 yard touchdown pass from Damon Huard early in the fourth quarter.

Cornerback Tyron Brackenridge, a rookie free agent, raced 50 yards for a score after Rivers was sacked and fumbled with just more than seven minutes left.

It was the third straight loss for the Chargers (1-3), which exceeds their loss total from last year, when they were an NFL-best 14-2 before their playoff pratfall against New England.

Colts 38, Broncos 20

At Indianapolis, the Colts relied on flawless execution to score on six of its last eight possessions, adding yet another anguishing chapter to Denver's recent rivalry with Indy.

The Colts (4-0) have won five of seven in the series since Tony Dungy took over as coach and extended their league-best winning streak to nine when counting last year's playoff games.

Despite overpowering the Colts with its usually efficient ground game in the first half, Denver (2-2) lost for the second straight week.

For a while, it appeared the Broncos had a winning combination, but the Colts' Peyton Manning and Joseph Addai ruined everything.

Cardinals 21, Steelers 14

At Glendale, Arizona, the Steelers were beaten at their own game by their old offensive coordinator and might-have-been head coach.

Rookie Steve Breaston returned a punt 73 yards for a touchdown and the Cardinals' defense shut down Pittsburgh's high-scoring offense most of the day to hand the Steelers their first loss.

Arizona first-year coach Ken Whisenhunt and top assistant Russ Grimm both were leading contenders to replace Bill Cowher in Pittsburgh after last season.

Whisenhunt was the Steelers' offensive coordinator and Grimm was the assistant head coach and offensive line coach at the time.

Instead, the job went to outsider Mike Tomlin.

Seahawks 23, 49ers 3

The 49ers Frank Gore funbles as the Seahawks swoop [EPA]

Deion Branch had seven catches for 130 yards for the Seahawks (3-1), who snapped a two-game losing streak against San Francisco (2-2).

Bernard made the biggest of Seattle's six first-half sacks on San Francisco's third play from scrimmage, piledriving Smith with every ounce of his 308-pound frame.

The impact injured Smith's right shoulder seriously enough to keep him out the rest of the day. He was replaced by Trent Dilfer.

Buccaneers 20, Panthers 7

At Charlotte, North Carolina, Jeff Garcia didn't throw an interception for the fourth straight game and ran for a touchdown, while Tampa Bay shut down David Carr, Steve Smith and Carolina to move atop the NFC South.

The 37-year-old Garcia, signed in the offseason, completed 15 of 25 passes for 176 yards and got Tampa Bay on the board with a 3-yard scramble on the Bucs' first possession.

Ike Hilliard caught seven passes for 114 yards, Michael Pittman rushed for 90 yards and the Buccaneers (3-1) overcame the loss of running back Carnell “Cadillac” Williams to a right knee injury to beat the Panthers (2-2) for only the second time in nine meetings.